Alzheimer disease model: EGb 761 shows promising results
2025-01-20
We are thrilled to announce the publication of the results from our research collaboration with Prof. Kristina Endres (University Medical Center Mainz) on the effects of Ginkgo biloba leaf extract EGb 761® in an Alzheimer's disease (AD) model.
The study, conducted on the 5xFAD mouse model, reveals promising results in improving cognitive function and reducing amyloid plaque load in the brain.
Key findings include:
✅ Improved cognitive function in 5xFAD mice
✅ Reduction in amyloid plaque load in the prefrontal cortex
✅ Sex-specific alterations in AD-related gene expression
✅ Anti-inflammatory effects both in the brain and peripherally
✅ Impact on disease-associated microglia (DAM2)
These results highlight the potential of EGb 761® as a multimodal treatment for cognitive deficits in Alzheimer's disease addressing both sex-specific and general mechanisms.
The publication can be found here: Ginkgo biloba extract EGb 761® ameliorates cognitive impairment and alleviates TNFα response in 5xFAD Alzheimer‘s disease model mice - ScienceDirect